I always felt really badly for Misao. One of her best friends just suddenly started hanging out with somebody else, and it's not like it's Misao's fault or anything. It's just a bit depressing to see her try hard to hang out with Kagami when the latter is being juggled between groups of people.
Granted, it's not the fault of any specific person, but still. You'd like Misao and Ayano could just start hanging out with Konata's group, but that'd probably be a bit awkward.